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Título : Polyamines inhibit both platelet aggregation and glycoprotein iib/iia activation
Creador: Corona de la Peña N
Nivel de acceso: Open access
Palabras clave : Inhibidores de Agregación Plaquetaria - Farmacología
Complejo GP b-a de Glicoproteína Plaquetaria - Metabolismo
Putrescina - Farmacología
Espermidina - farmacología
Platelet Aggregation/drug effects
Platelet Aggregation Inhibitors - Pharmacology
Platelet Glycoprotein GPIIb-IIIa Complex - Metabolism
Putrescine - Pharmacology
Spermidine - Pharmacology
Descripción : Platelet aggregation is inhibited by the polyamines putrescine, spermidine, and spermine. To date, the mechanism of action has not been clearly identified. Evidence suggests that polyamines may interact with the fibrinogen receptor (GP IIb/IIIa), interfering with platelet-platelet attachment. The effect of polyamines on human platelet aggregation and GP IIb/IIIa activation was evaluated. For the aggregation experiments, platelets were obtained from heparin- or citrate-collected blood. Our results indicate that the polyamines putrescine, spermidine, and spermine cause a dose-dependent inhibition of ADP- or collagen-mediated platelet aggregation with an order of potency spermine>spermidine>putrescine. In addition, spermine arrests or inhibits thrombin-, epinephrine-, arachidonate-, or ristocetin-induced platelet aggregation. Expression of platelet membrane glycoproteins IIb, IIIa, and IX is not reduced by polyamines. However, spermine inhibits the ADP- or thrombin-induced activation of GP IIb/IIIa. It is concluded that the final step in aggregation, common to all agonists, ie, fibrinogen binding to GP IIb/IIIa, is inhibited by spermine through inhibition of the agonist-induced activation of GP IIb/IIIa that precedes fibrinogen-ligand binding
Colaborador(es) u otros Autores:  Uribe Carvajal S
 Barrientos Rios R
 Matias Aguilar L
 Montiel Manzano G
 Majluf Cruz A
Fecha de publicación : 2005
Tipo de publicación: Artículo
Formato: pdf
Fuente: J Cardiovasc Pharm 46(2):216-221
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2697
Idioma: eng
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