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Título : Pontine and cerebellar norepinephrine content in adult rats recovering from focal cortical injury
Creador: Gonzalez Pina, Rigoberto 
Nivel de acceso: Open access
Palabras clave : Cerebelo - metabolismo - Ratas
Cerebelo - fisiopatología - Ratas
Lateralidad Funcional - fisiología - Ratas
Técnicas In Vitro - Ratas
Locomoción - fisiología - Ratas
Corteza Motora - lesiones - Ratas
Corteza Motora - fisiopatología - Ratas
Norepinefrina - metabolismo - Ratas
Puente - metabolismo - Ratas
Puente - fisiopatología - Ratas
Ratas Wistar
Cerebellum - metabolism - Rats
Cerebellum - physiopathology - Rats
Functional Laterality - physiology - Rats
In Vitro Techniques - Rats
Locomotion - physiology - Rats
Motor Cortex - injuries - Rats
Motor Cortex - physiopathology - Rats
Norepinephrine - metabolism - Rats
Pons - metabolism- Rats
Pons - physiopathology - Rats
Rats, Wistar
Norepinefrina
lesión cerebral
cerebelo
protuberancia
diasquisis
Norepinephrine
Brain injury
Pons
Cerebellum
Diaschisis
Descripción : Norepinephrine (NE) plays an important role in motor recovery after brain damage. Most studies concerning NE activity have been performed in the cerebellum, while the role of the pons, the site where the norepinephrinergic locus coeruleus is located, has not yet been elucidated. For this work, we studied the changes in cerebellar and pontine NE content in sham-operated (n = 17), motor cortex injured (n = 6) and recovered rats (n = 12). Motor effects were assessed by means of footprint analysis and sensorimotor evaluation. It was found that after cortical brain damage, the stride length decreases while the stride angle increases after 6 h post-surgery, while the sensorimotor evaluation showed an increase in the motor deficit. Recovery was observed after 24 h. NE content increased in the pons after 6 h and returned to normal levels in recovered rats, with no significant changes observed in the cerebellum. Based on the functional remote inhibition, it is possible that NE exerts an autoinhibitory effect in the pons after motor cortical ablation. On the other hand, the absence of an effect in the cerebellum suggests that cerebellar NE activity related to damage and/or recovery is limited to discrete areas of the structure. © 2006 Springer Science+Business Media, LLC.
Colaborador(es) u otros Autores: Bueno-Nava A
Montes S
Alfaro-Rodriguez A
Gonzalez-Maciel A
Reynoso-Robles R
Ayala-Guerrero F
Fecha de publicación : 2006
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1007/s11064-006-9196-6
Fuente: Neurochemical Research 31(12):1443 - 1449
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2700
Idioma: eng
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