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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2747| Título : | Pyridoxine and Zanamivir Alter Levels of Dopamine in Brain of Rats with Induced Hyperglycemia by Inhibition of Oxidative Stress |
| Creador: | Calderón Guzmán, David |
| Nivel de acceso: | Open access |
| Palabras clave : | Piridoxina - administración & dosificación Piridoxina - líquido cefalorraquídeo Piridoxina - sangre Zanamivir - administración & dosificación Zanamivir - líquido cefalorraquídeo Zanamivir - sangre Estrés Oxidativo Biomarcadores - sangre Biomarcadores - líquido cefalorraquídeo Corteza Cerebral - cirugía Corteza Cerebral - patología Dopamina - líquido cefalorraquídeo Dopamina - sangre Glutatión - líquido cefalorraquídeo Glutatión - sangre Peroxidación de Lípido - Efectos de drogas Infusiones Parenterales - utilización Encéfalo - Efectos de drogas Ratas Ratas Wistar Adenosina Trifosfatasas - sangre Adenosina Trifosfatasas - líquido cefalorraquídeo Pyridoxine - administration & dosage Pyridoxine - cerebrospinal fluid Pyridoxine - blood Zanamivir - administration & dosage Zanamivir - - cerebrospinal fluid Zanamivir - - blood Oxidative Stress Biomarkers - blood Biomarkers - cerebrospinal fluid Cerebral Cortex - surgery Cerebral Cortex - pathology Dopamine - cerebrospinal fluid Dopamine - blood Glutathione - cerebrospinal fluid Glutathione - blood Lipid Peroxidation - drug effects Infusions, Parenteral - utilization Brain - drug effects rats Rats, Wistar Adenosine Triphosphatases - blood Adenosine Triphosphatases - cerebrospinal fluid Antiviral, cerebro, dopamina, piridoxina, estrés oxidativo Antiviral, brain, dopamine, pyridoxine, oxidative stress |
| Descripción : | The aim of this study was to evaluate the effect of pyridoxine and zanamivir on dopamine (DA) levels and biomarkers of oxidative stress in brain of rats in presence of sucrose. Thirty six Wistar rats divided in six groups, comprising of 6 rats each. The rats were made to receive for 5 consecutive days intraperitoneal administrations of the following: group 1 (saline solution (NaCl 0.9%), control), group 2 (zanamivir 2.5 mg kgG1 ), group 3 (pyridoxine 10 mg kgG1 ), group 4 (sucrose 20%), group 5 (zanamivir+sucrose) and group 6 (pyridoxine+sucrose). The animals were sacrificed at the end of treatment and their brains were dissected in cortex, hemispheres, cerebellum/stem to measure dopamine (DA), glutathione (GSH), lipoperoxidation (TBARS) and enzymatic activities of ATPase using previously validated methods. The levels of glucose were not altered in rats treated with zanamivir and pyridoxine in presence of sucrose. In hemispheres, the levels of DA decreased in groups 3 (pyridoxine) and 4 (sucrose). Glutathione increased in the groups 5 (zanamivir+sucrose) and 6 (pyridoxine+sucrose). In cerebellum/medulla oblongata, DA increased in groups 2 (zanamivir), 3, 5 and 6. In cerebellum/medulla oblongata and cortex peroxidation decreased in group 2, while ATPase activity increased in groups 2 and 3 in cortex regions. Alterations of dopamine levels were seen in animals treated with pyridoxine and zanamivir. Reduction of oxidative stress may be involved in these effects. |
| Colaborador(es) u otros Autores: | Hernández García Ernestina Barragán Mejía Gerardo Juárez Tapia B Trujillo Jiménez Francisca Juárez Olguín Mateo Hugo Santamaria Del Angel David |
| Fecha de publicación : | 2016 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.3923/ijp.2016.161.168 |
| Fuente: | Int J Pharmacol 12(3):161-168 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2747 |
| Idioma: | spa |
| Aparece en las colecciones: | Artículos |
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