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Título : Pyridoxine, regardless of serotonin levels, increases production of 5-hydroxytryptophan in rat brain
Creador: Calderón Guzmán, David
Nivel de acceso: Open access
Palabras clave : 5-Hidroxitriptófano - Metabolismo
Antioxidantes - Química
Antioxidantes - Farmacología
Encéfalo - Efecto de drogas
5-Hydroxytryptophan - Metabolism
Antioxidants - Chemistry
Antioxidants - Pharmacology
Brain - Drug effects
Aminas biogénicas
Cerebro
Peroxidación de lípidos
Pyridoxine
Serotonina
Vitaminas.
Biogenic amines
Brain
Lipid peroxidation
Pyridoxine
Serotonin
Vitamins.
Descripción : Background The aim of this study was to evaluate effects of pyridoxine and butylated hydroxytoluene (BHT) on lipid peroxidation and on levels of 5-hydroxytryptophan and serotonin. Methods Thirty rats (30 days of age) were used in the survey, measuring levels of lipid peroxidation (TBARS), hemoglobin, 5-hydroxytryptophan (5-HTP), and serotonin (5-HT) after intraperitoneal (i.p.) injections of 4 and 10 mg/kg/day of pyridoxine HCl during 20 days and a single dose of 2 μM/kg (440 μg) of BHT. Results Levels of TBARS and 5-HTP increased considerably (p <0.05) in all vitamin- and/or BHT-treated groups, and 5-HT increased partially (p <0.05) only in B6 with or without BHT-treated groups compared with control group. Conclusions Results suggest that pyridoxine plays a role in tryptophan metabolism, increasing production of 5-HTP. © 2004 IMSS. Published by Elsevier Inc.
Colaborador(es) u otros Autores: Hernandez Islas Jose Luis
Espitia Vazquez Ivonne
Barragan Mejıa Gerardo
Hernandez Garcıa Ernestina
Santamarıa del Angel Daniel
Juarez Olguín Hugo
Fecha de publicación : 2004
Tipo de publicación: Revisión
Formato: pdf
Identificador del Recurso : 10.1016/j.arcmed.2004.03.003
Fuente: Archives of Medical Research 35(4):271 - 274
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2748
Idioma: eng
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