Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2761
Título : Relationship between clinical and biologic variables and chloramphenicol pharmacokinetic parameters inpediatric patients with sepsis
Creador: Lugo Goytia, G
Nivel de acceso: Open access
Palabras clave : Agentes Antibacterianos - farmacocinética
Agentes Antibacterianos - uso terapéutico
Teorema de Bayes - Niño
Cloranfenicol - farmacocinética
Cloranfenicol - uso terapéutico
Sepsis - quimioterapia
Sepsis - epidemiología
Sepsis - metabolismo
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
Bayes Theorem - Child
Chloramphenicol - pharmacokinetics
Chloramphenicol -therapeutic use
Sepsis - drug therapy
Sepsis - epidemiology
Sepsis - metabolism
cloranfenicol
covariables
farmacocinética
regresión múltiple
sepsis
chloramphenicol
covariates
pharmacokinetics
multiple regression
sepsis
Descripción : OBJECTIVE: To evaluate the influence of several clinical and biologic factors on the disposition kinetics of oral chloramphenicol in pediatric patients and to determine the usefulness of this information to predict chloramphenicol serum concentrations. STUDY DESIGN: The clinical, biologic, and pharmacokinetic data of 30 consecutive pediatric patients diagnosed with sepsis and admitted to a tertiary care center were analyzed retrospectively. The patients were randomly assigned to a study group and a validation group. The model was developed by a three-step approach involving Bayesian estimation of pharmacokinetic parameters, selection of covariates by principal component analysis, and final selection by stepwise multiple linear regression. The model was tested in the study group and compared with a general population model using a prediction error analysis. RESULTS: Regression analysis revealed that weight, albumin, and white blood cell (WBC) count were the most important determinants for chloramphenicol distribution volume, whereas age, WBC count, and serum creatinine were the most important determinants for chloramphenicol clearance. The performance of the constructed population model improved significantly in terms of both bias and precision compared with the general model when tested in the validation group. CONCLUSIONS: Clinical and biologic factors may significantly influence chloramphenicol's disposition in pediatric patients with sepsis and therefore should be considered in programming dosage regimens
Colaborador(es) u otros Autores: Lares Asseff Ismael
Pérez Guillé MG
Pérez AG
Mejía CL
Fecha de publicación : 2000
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1345/aph.19050
Fuente: Ann Pharmacother 34(3):393-397
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2761
Idioma: eng
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