Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2764
Título : Adverse Effects of Imipramine are Increased by Interaction with ASA in Depressed Patients
Creador: Juárez Olguín, Mateo Hugo
Nivel de acceso: Open access
Palabras clave : Imipramina - análisis
Imipramina - efectos adversos
Imipramina - sangre
Imipramina - uso terapéutico
Aspirina - uso terapéutico
Aspirina - análisis
Proteínas Portadoras - farmacocinética
Antidepresivos - farmacología
Imipramine - analysis
Imipramine - Adverse Effects
Imipramine - blood
Imipramine - therapeutic use
Aspirin - therpeutic use
Aspirin- analysis
Carrier Proteins - pharmacokinetics
Antidepressive Agents - pharmacology
Imipramina
efectos adversos
pacientes con depresión
Imipramine
Adverse Effects
Depressed Patients
Descripción : Because protein binding is a process that can be changed by the presence of other drugs with similar or greater affinity for proteins than the original compound, this causes a greater concentration of the free drug, while potentializing adverse effects, the most important factor responsible for noncompliance (Demyttenaere 1997; Fincke et al. 1998). The purpose of this study was to measure the binding of imipramine to plasma proteins when administered simultaneously with acetyl salicylic acid (ASA). Such interaction would be more clearly defined using clinical assessment parameters in patients treated with imipramine, who additionally need the second drug. The study was carried out in 20 clinically diagnosed depressed patients (16 F, 4 M, average age 38.3 6 13.3 years and weight 63.8 6 9.0 kg) to which imipramine (Tofranil) was administered at doses of 75 mg every 12 h. Informed consent was obtained for all patients before the study.
Colaborador(es) u otros Autores: Jung-Cook Helgi
Flores Pérez Janett
 Lares-Asseff Ismael
Fecha de publicación : 2000
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/S0893-133X(99)00087-1
Fuente: Neuropsychopharmacol 22(1):100-101
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2764
Idioma: eng
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