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Título : Reliable method for the determination of ranitidine by liquid chromatography using a microvolume of plasma
Creador: Flores Pérez, Carmen
Nivel de acceso: Open access
Palabras clave : Cromatografía Líquida de Alta Presión - métodos
Antagonistas de los Receptores Histamínicos H2 - sangre
Ranitidina - sangre
Reproducibilidad de Resultados
Espectrofotometría Ultravioleta - métodos
Chromatography, High Pressure Liquid - methods
Histamine H2 Antagonist - blood
Ranitidine - blood
Reproducibility of Results
Spectrophotometry, Ultraviolet - methods
Ranitidina
Ranitidine
Descripción : The aim of the present study was to develop a simple method to measure ranitidine, using 100 μl of plasma, by high-performance liquid chromatography with a Symmetry C18 column and UV detection at 313 nm. Linearity was assessed in the range from 50 to 1500 ng ml-1 and had a correlation coefficient of 0.999. The inter- and intra-day coefficients of variation were less than 7%. The limits of detection and quantitation were 5 and 15 ng ml-1, respectively. Drug levels were determined satisfactorily in three patients. A simple and reliable method was developed which uses a microvolume of plasma, particularly useful in low-weight children. © 2003 Elsevier B.V. All rights reserved.
Colaborador(es) u otros Autores: Juárez Olguín H
Flores Pérez J
Toledo López A
Lares Asseff I
Alvarez García C
Fecha de publicación : 2003
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/S1570-0232(03)00474-4
Fuente: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 795(1):141 - 144
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2766
Idioma: eng
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