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Título : Short report: limited and short-lasting humoral response in Taenia solium: seropositive households compared with patients with neurocysticercosis
Creador: Meza Lucas A
Nivel de acceso: Open access
Palabras clave :  Antígenos Helmínticos - inmunología
Encefalopatías - epidemiología
Encefalopatías - inmunología
Neurocisticercosis - epidemiología
Neurocisticercosis - inmunología
Taenia - inmunología
Antigens, Helminth - immunology
Brain Diseases - epidemiology
Brain Diseases - immunology
Neurocysticercosis - epidemiology
Neurocysticercosis - immunology
Taenia - immunology
Descripción : Epidemiologic data suggest that 30-40% of Taenia solium-seropositive people become spontaneously negative without acquiring cysticercosis. To compare the responses of these individuals with those of patients with neurocysticercosis, we screened seropositive persons among family members of 16 patients. We searched for specific antibodies in patients and their 118 households by an enzyme-linked immunoelectrotransfer blot assay using specific glycoproteins of T. solium metacestodes. We found six seropositive individuals without neurocysticercosis among members of four families. The matching patients were young, harbored viable cysts, and had short evolution of disease. The baseline response of healthy seropositive individuals was scarce and showed a low frequency of antibodies against glycoproteins GP39-42 and GP24, which are immunodominant in patients with neurocysticercosis. Moreover, they became spontaneously negative in few months. The response of patients was heterogeneous as shown in other studies. The results of this work support a highly dynamic host-parasite immunologic interaction and suggest individual susceptibility or level of exposure among family members
Colaborador(es) u otros Autores: Carmona Miranda L
García Jerónimo RC
Torrero Miranda A
González Hidalgo G
López Castellanos G
Correa D
Fecha de publicación : 2003
Tipo de publicación: Artículo
Formato: pdf
Fuente: Am J Trop Med Hyg 69(2):223-227
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2812
Idioma: spa
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