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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2820| Título : | Age-related sex differences in glutathione peroxidase and oxidative DNA damage in a healthy mexican population |
| Creador: | Mendoza Núñez V.M |
| Nivel de acceso: | Open access |
| Palabras clave : | Adulto Factores de Edad Ensayo Cometa Estudios Transversales | | Daño del ADN Femenino Glutatión Peroxidasa - sangre Humanos Lipid Peroxides - sangre Masculino México Mediana Edad Estrés Oxidativo - fisiología Factores Sexuales Hábito de Fumar Superóxido Dismutasa - sangre Encuestas y Cuestionarios Sustancias Reactivas al Ácido Tiobarbitúrico - análisis Adulto Joven Adult Age Factors Comet Assay Cross-Sectional Studies DNA Damage Female Glutathione Peroxidase - blood Humans Lipid Peroxides - blood Male Mexico Middle Aged Oxidative Stress - physiology Sex Factors Smoking Superoxide Dismutase - blood Surveys and Questionnaires Thiobarbituric Acid Reactive Substances - analysis Young Adult |
| Descripción : | Background and objective: It has been proposed that women have an estrogen activity-linked biological antioxidant advantage and that this advantage is lost in the postmenopausal stage. The latter remains controversial. Our aim was to determine age-related sex differences in oxidative stress and oxidative DNA damage in a healthy Mexican population. Methods: A cross-sectional and comparative study was carried out in a convenience sample of 162 healthy subjects aged as follows: (1) 25-44 years (n=35 women and 38 men), (2) 45-64 years (n=41 women and 27 men), and (3) ≥65 years (n=13 women and 8 men). We measured plasma lipoperoxides (LPO), superoxide dismutase (SOD), glutathione peroxidase (GPx), and DNA damage by comet assay. Results: We found greater activity of GPx in women than in men according to age increase (p<0.05). This activity is maintained in old age in women. In contrast, men exhibited a significant diminution in GPx according to age increase. Similarly, we observed a greater percentage of cells without oxidative DNA damage in women in the 45-64-years age group and in the group of women aged ≥65 years. Conclusions: Our findings suggest that women have a more efficient antioxidant activity than men, which has been linked with the greater longevity observed in women. © 2010, Mary Ann Liebert, Inc. |
| Colaborador(es) u otros Autores: | Beristain-Pérez A. Pérez-Vera S.P. Altamirano-Lozano M.A. |
| Fecha de publicación : | 2010 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1089/jwh.2009.1684 |
| Fuente: | Journal of Women's Health 19(5):919 - 926 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2820 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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