Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2842
Título : Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression
Creador: Thomson E.M.,
Nivel de acceso: Open access
Palabras clave : Administración por Inhalación
Contaminación del Aire - Efectos adversos
Animales
Encéfalo - efectos de drogas
Encéfalo - metabolismo
Endotelina-1 - genética
Expresión Génica - efectos de drogas
masculino
Óxido Nítrico Sintasa de Tipo II - genética
Ozono - toxicidad
Material Particulado - toxicidad
Hipófisis - efectos de drogas
Hipófisis - metabolismo
ARN Mensajero - metabolismo
Ratas
Ratas Consanguíneas F344
Factor de Necrosis Tumoral alfa - genética
Administration, Inhalation
Air Pollution - adverse effects
Animals
Brain - drug effects
Brain - metabolism
Endothelin-1 - genetics
Gene Expression - drug effects
Male
Nitric Oxide Synthase Type II - genetics
Ozone - toxicity
Particulate Matter - toxicity
Pituitary Gland - drug effects
Pituitary Gland - metabolism
RNA, Messenger - metabolism
Rats
Rats, Inbred F344
Tumor Necrosis Factor-alpha - genetics
Contaminación del Aire
Cerebro
Óxido Nítrico Sintetasa de Tipo II
Ozono
Material Particulado
Pituitaria
Air pollution
Brain
Endothelin
Inducible nitric oxide synthase (iNOS)
Ozone
Particulate matter
Pituitary
Descripción : Recent work suggests that air pollution is a risk factor for cerebrovascular and neurodegenerative disease. Effects of inhaled pollutants on the production of vasoactive factors such as endothelin (ET) and nitric oxide (NO) in the brain may be relevant to disease pathogenesis. Inhaled pollutants increase circulating levels of ET-1 and ET-3, and the pituitary is a potential source of plasma ET, but the effects of pollutants on the expression of ET and NO synthase genes in the brain and pituitary are not known. In the present study, Fischer-344 rats were exposed by nose-only inhalation to particles (0, 5, 50 mg/m3 EHC-93), ozone (0, 0.4, 0.8 ppm), or combinations of particles and ozone for 4 h. Real-time reverse transcription polymerase chain reaction was used to measure mRNA levels in the cerebral hemisphere and pituitary 0 and 24 h post-exposure. Ozone inhalation significantly increased preproET-1 but decreased preproET-3 mRNAs in the cerebral hemisphere, while increasing mRNA levels of preproET-1, preproET-3, and the ET-converting enzyme (ECE)-1 in the pituitary. Inducible NO synthase (iNOS) was initially decreased in the cerebral hemisphere after ozone inhalation, but increased 24 h post-exposure. Particles decreased tumour necrosis factor (TNF)-α mRNA in the cerebral hemisphere, and both particles and ozone decreased TNF-α mRNA in the pituitary. Our results show that ozone and particulate matter rapidly modulate the expression of genes involved in key vasoregulatory pathways in the brain and pituitary, substantiating the notion that inhaled pollutants induce cerebrovascular effects. Crown Copyright © 2007.
Colaborador(es) u otros Autores: Kumarathasan P.
Calderón-Garcidueñas L.
Vincent R.
Fecha de publicación : 2007
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/j.envres.2007.06.005
Fuente: Environmental Research 105(2):224 - 233
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2842
Idioma: eng
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