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Título : Susceptibility of Mexican isolates of yeasts and moulds to amphotericin B and triazole antifungals
Creador: Arredondo García, José Luis
Nivel de acceso: Open access
Palabras clave : Anfotericina B - farmacologia - humans - México
Antifúngicos - farmacologia - humans - México
Farmacorresistencia Fúngica - humans - México
Hongos - clasificación - humans - México
Hongos - efectos de drogas - humans - México
Hongos - aislamiento & purificación - humans - México
Pruebas de Sensibilidad Microbiana - humans - México
Micosis - microbiologia - humans - México
Triazoles - farmacologia - humans - México
Población Urbana
Amphotericin B - pharmacology - humans - Mexico
Antifungal Agents - pharmacology - humans - Mexico
Drug Resistance, Fungal - humans - Mexico
Fungi - classification - humans - Mexico
Fungi - drug effects - humans - Mexico
Fungi - isolation & purification - humans - Mexico
Microbial Sensitivity Tests - - humans - Mexico
Mycoses - microbiology - humans - Mexico
Triazoles - pharmacology - humans - Mexico
Urban Population
Candida spp, moldes, susceptibilidad in vitro, azoles, anfotericina B
Candida spp., moulds, in vitro susceptibility, azoles, amphotericin B
Descripción : Background: Resistance to antifungal drugs, especially towards triazoles, is commonly referred to by clinicians, but data on its prevalence in developing countries is limited. Methodology: To determine the prevalence of triazole-resistance amongst pathogenic yeasts and moulds, we assessed the in vitro susceptibility of 250 isolates from hospitalized patients at five Mexican cities towards amphotericin B, fluconazole and voriconazole, by E-test. Results: All yeasts were susceptible to voriconazole, according to E-test interpretive criteria (MIC ≤ 1 μg/mL), and all filamentous or dimorphic fungi also had voriconazole MIC ≤ 1 μg/mL, except for one isolate each of Mucor sp. and Acremonium sp. Candida krusei and one isolate of C. glabrata were resistant to fluconazole, a drug that had MIC ≤ 192 μg/mL for filamentous fungi. Although no breakpoints for amphotericin B are available, all three C. krusei, 2/25 C. glabrata, 3/ 22 C. parapsilosis and 1/108 C. albicans had MIC ≤ 2 μg/mL. Conclusion: In vitro, voriconazole is active against yeasts and moulds commonly causing severe mycoses in Mexico. Copyright © 2009 Arredondo-Garcia et al.
Colaborador(es) u otros Autores: Amábile-Cuevas CF
Fecha de publicación : 2009
Tipo de publicación: Artículo
Formato: pdf
Fuente: Journal of Infection in Developing Countries 3(5):398 - 401
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2848
Idioma: eng
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