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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2885| Título : | The maintenance of hippocampal pyramidal neuron populations is dependent on the modulation of specific cell cycle regulators by thyroid hormones |
| Creador: | Alva Sánchez C |
| Nivel de acceso: | Open access |
| Palabras clave : | Antitiroideos - farmacologia - ratas Ciclo Celular - genética - ratas Proteínas de Ciclo Celular - genética - ratas Proteínas de Ciclo Celular - metabolismo - ratas Proliferación de la Célula - genética - ratas Supervivencia Celular - genética - ratas Ciclina D1 - genética - ratas Ciclina D1 - metabolismo - ratas Inhibidor p21 de las Quinasas Dependientes de la Ciclina - genética - ratas Inhibidor p21 de las Quinasas Dependientes de la Ciclina - metabolismo - ratas Hipocampo - citología - ratas Hipocampo - metabolismo - ratas Hipotiroidismo - inducido químicamentea - ratas Hipotiroidismo - metabolismo - ratas Hipotiroidismo - fisiopatologia - ratas Metimazol - farmacologia - ratas Antígeno Nuclear de Célula en Proliferación - genética - ratas Antígeno Nuclear de Célula en Proliferación - metabolismo - ratas Proteínas Proto-Oncogénicas c-bcl-2 - genética - ratas Proteínas Proto-Oncogénicas c-bcl-2 - metabolismo - ratas Células Piramidales - citología - ratas Células Piramidales - metabolismo - ratas Ratas Wistar Glándula Tiroides - efectos de drogas - ratas Glándula Tiroides - metabolismo - ratas Glándula Tiroides - fisiopatologia - ratas Hormonas Tiroideas - metabolismo - ratas Hormonas Tiroideas - farmacologia - ratas Proteína p53 Supresora de Tumor - genética - ratas Proteína p53 Supresora de Tumor - metabolismo - ratas Proteína X Asociada a bcl-2 - genética - ratas Proteína X Asociada a bcl-2 - metabolismo - ratas Antithyroid Agents - pharmacology - rats Cell Cycle - genetics - rats Cell Cycle Proteins - genetics - rats Cell Cycle Proteins - metabolism - rats Cell Proliferation - genetics - rats Cell Survival - genetics - rats Cyclin D1 - genetics - rats Cyclin D1 - metabolism - rats Cyclin-Dependent Kinase Inhibitor p21 - genetics - rats Cyclin-Dependent Kinase Inhibitor p21 - metabolism - rats Hippocampus - cytology - rats Hippocampus - metabolism - rats Hypothyroidism - chemically induced - rats Hypothyroidism - metabolism - rats Hypothyroidism - physiopathology - rats Methimazole - pharmacology - rats Proliferating Cell Nuclear Antigen - genetics - rats Proliferating Cell Nuclear Antigen - metabolism - rats Proto-Oncogene Proteins c-bcl-2 - genetics - rats Proto-Oncogene Proteins c-bcl-2 - metabolism - rats Pyramidal Cells - cytology - rats Pyramidal Cells - metabolism - rats Rats, Wistar Thyroid Gland - drug effects - rats Thyroid Gland - metabolism - rats Thyroid Gland - physiopathology - rats Thyroid Hormones - metabolism - rats Thyroid Hormones - pharmacology - rats Tumor Suppressor Protein p53 - genetics - rats Tumor Suppressor Protein p53 - metabolism - rats bcl-2-Associated X Protein - genetics - rats bcl-2-Associated X Protein/metabolism - rats Apoptosis, Ciclina D1, PCNA, Bax/Bcl-2, Hipotiroidismo Apoptosis Cycline D1 PCNA Bax/Bcl-2 Hypothyroidism |
| Descripción : | The onset of adult hypothyroidism causes neuronal damage in the CA3 hippocampal region, which is attenuated by T(4) administration. We analyzed the expression of molecular proliferation markers (Cyclin D1 and PCNA), cellular damage-arrest (p53 and p21), and apoptosis (Bax/Bcl-2 index) in the hippocampus of hypothyroid (methimazole; 60 mg/kg) or thyroid replaced (T(4), 20 microg/kg; MMI+T(4) or T(3), 20 microg/kg; MMI+T(3)) adult male rats. Histological analysis showed that hypothyroid animals exhibit significant neuronal damage in all regions of the hippocampus accompanied by the triggering of the apoptotic pathway (increases in p53, p21 and the Bax/Bcl-2 index) and no changes in proliferation (Cyclin D1 and PCNA). MMI+T(4) replaced animals were completely protected with no changes in molecular markers. In contrast, MMI+T(3) replaced animals showed partial protection in which, although pro-apoptotic effects remained (increase in the Bax/Bcl-2), proliferative mechanisms were triggered (increase in p53, Cyclin D1 and PCNA expression). Our results indicate that thyroid hormones participate in the maintenance of the hippocampal neuronal population even in adulthood, suggesting that THs have different physiological roles as neuronal survival factors: T(4) prevents the activation of apoptotic pathways, whereas T(3) activates cell differentiation and proliferation mechanisms |
| Colaborador(es) u otros Autores: | Sánchez-Huerta K Arroyo-Helguera O Anguiano B Aceves C Pacheco-Rosado J |
| Fecha de publicación : | 2009 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1016/j.brainres.2009.02.043 |
| Fuente: | Brain Res 1271():27-35 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2885 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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