Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2903
Título : The effect of estrogen on testicular gonocyte maturation
Creador: Vigueras Villaseñor, Rosa María
Nivel de acceso: Open access
Palabras clave : Animales Recién Nacidos - ratas
Apoptosis - efectos de drogas - ratas
Diferenciación Celular - efectos de drogas - ratas
Movimiento Celular - efectos de drogas - ratas
Proliferación de la Célula - efectos de drogas - ratas
Estradiol - toxicidad - ratas
Fertilidad - efectos de drogas - ratas
Ratas Wistar - ratas
Espermatozoides - efectos de drogas - ratas
Espermatozoides - patología - ratas
Testículo - efectos de drogas - ratas
Testículo - patología - ratas
Animals, Newborn - Rats
Apoptosis - drug effects - Rats
Cell Differentiation - drug effects - Rats
Cell Movement - drug effects - Rats
Cell Proliferation - drug effects - Rats
Estradiol - toxicity - Rats
Fertility - drug effects - Rats
Rats, Wistar - Rats
Spermatozoa - drug effects - Rats
Spermatozoa - pathology - Rats
Testis - drug effects - Rats
Testis - pathology - Rats
Estradiol
Gonocitos
Fertilidad
Masculinos
Estradiol
Gonocytes
Fertility
Males
Descripción : During the first days of postnatal life in rats the male germ cells (gonocytes) proliferate and move towards the seminiferous tubule basal lamina maturing into spermatogonia. This process is necessary for spermatogenesis and can be affected by estrogen (E); therefore, it is important to determine whether the damaging mechanism induced by E administration during the postnatal period impairs gonocyte maturation. One-day-old rat pups were given 1 microg 17-beta-estradiol daily and studied at 3, 5, 8, 10 and 16 days of age, corresponding to the critical gonocyte differentiation period in the rat. Testicles were isolated and the number of gonocytes in contact with the basal lamina of the seminiferous tubule was estimated, as well as the proliferation rate and apoptosis of the gonocytes. We observed that the administration of E changed the migration of gonocytes towards the basal lamina, decreased cell proliferation and increased apoptosis, resulting in a decrease in spermatogonia and spermatocytes. The migration of gonocytes and subsequent proliferation is required for survival of this germ cell type. The lack of maturation and the death of gonocytes could be one of the causes of infertility following exogenous E treatment
Colaborador(es) u otros Autores: Moreno-Mendoza Na
Reyes-Torres G Molina-Ortiz D
Cárdenas-León M
Rojas-Castañeda Jc.
Fecha de publicación : 2006
Tipo de publicación: Artículo
Formato: PDF
Identificador del Recurso : 10.1016/j.reprotox.2006.03.008
Fuente: Reprod Toxicol 22(3):513-520
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2903
Idioma: eng
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