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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2903
Título : | The effect of estrogen on testicular gonocyte maturation |
Creador: | Vigueras Villaseñor, Rosa María |
Nivel de acceso: | Open access |
Palabras clave : | Animales Recién Nacidos - ratas Apoptosis - efectos de drogas - ratas Diferenciación Celular - efectos de drogas - ratas Movimiento Celular - efectos de drogas - ratas Proliferación de la Célula - efectos de drogas - ratas Estradiol - toxicidad - ratas Fertilidad - efectos de drogas - ratas Ratas Wistar - ratas Espermatozoides - efectos de drogas - ratas Espermatozoides - patología - ratas Testículo - efectos de drogas - ratas Testículo - patología - ratas Animals, Newborn - Rats Apoptosis - drug effects - Rats Cell Differentiation - drug effects - Rats Cell Movement - drug effects - Rats Cell Proliferation - drug effects - Rats Estradiol - toxicity - Rats Fertility - drug effects - Rats Rats, Wistar - Rats Spermatozoa - drug effects - Rats Spermatozoa - pathology - Rats Testis - drug effects - Rats Testis - pathology - Rats Estradiol Gonocitos Fertilidad Masculinos Estradiol Gonocytes Fertility Males |
Descripción : | During the first days of postnatal life in rats the male germ cells (gonocytes) proliferate and move towards the seminiferous tubule basal lamina maturing into spermatogonia. This process is necessary for spermatogenesis and can be affected by estrogen (E); therefore, it is important to determine whether the damaging mechanism induced by E administration during the postnatal period impairs gonocyte maturation. One-day-old rat pups were given 1 microg 17-beta-estradiol daily and studied at 3, 5, 8, 10 and 16 days of age, corresponding to the critical gonocyte differentiation period in the rat. Testicles were isolated and the number of gonocytes in contact with the basal lamina of the seminiferous tubule was estimated, as well as the proliferation rate and apoptosis of the gonocytes. We observed that the administration of E changed the migration of gonocytes towards the basal lamina, decreased cell proliferation and increased apoptosis, resulting in a decrease in spermatogonia and spermatocytes. The migration of gonocytes and subsequent proliferation is required for survival of this germ cell type. The lack of maturation and the death of gonocytes could be one of the causes of infertility following exogenous E treatment |
Colaborador(es) u otros Autores: | Moreno-Mendoza Na Reyes-Torres G Molina-Ortiz D Cárdenas-León M Rojas-Castañeda Jc. |
Fecha de publicación : | 2006 |
Tipo de publicación: | Artículo |
Formato: | |
Identificador del Recurso : | 10.1016/j.reprotox.2006.03.008 |
Fuente: | Reprod Toxicol 22(3):513-520 |
URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2903 |
Idioma: | eng |
Aparece en las colecciones: | Artículos |
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