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Título : Tissue-specific induction of the carcinogen-inducible cytochrome P450 isoforms in the gastrointestinal tract
Creador: Nancy Hernandez Martınez
Nivel de acceso: Open access
Palabras clave : Esteroide 17-alfa-Hidroxilasa - farmacología - ratas
Esteroide 17-alfa-Hidroxilasa - efecto de drogas - ratas
Esteroide 17-alfa-Hidroxilasa - toxicidad - ratas
Inducción Enzimática - efecto de drogas - ratas
Tracto Gastrointestinal - anatomía & histología - ratas
Tracto Gastrointestinal - enzimología - ratas
Fenobarbital - uso terapéutico - ratas
Ratas Wistar
Steroid 17-alpha-Hydroxylase - pharmacology - rats
Steroid 17-alpha-Hydroxylase - drug effects - rats
Steroid 17-alpha-Hydroxylase - toxicity - rats
Enzyme Induction - drug effects - rats
Gastrointestinal Tract - anatomy & histology - rats
Gastrointestinal Tract - enzymology - rats
Phenobarbital - therpeutic use - rats
Rats, Wistar
Cytochrome P450
Gastrointestinal tract
Inducers
Descripción : Gastrointestinal tissues are directly exposed to dietary xenobiotics. In spite of this, modulation of cytochrome P450 (CYP) enzymes in the gastrointestinal tract is not well established. CYP induction could facilitate transformation of chemical agents to potentially toxic or carcinogenic metabolites. This might also determine drug efficacy, burden of foreign chemicals on tissues or bioavailability of certain therapeutic agents. In order to assess the induction of the CYP subfamilies 1A1/2, 2B1/2, 2E1 and 3A2 in the gastrointestinal tract, male Wistar rats were treated with phenobarbital/β-naphthoflavone (PB/NF), cyclohexanol/albendazole (CH/ABZ) or toluene (TL). Microsomal fractions were prepared from tissue samples of the esophagus, the stomach, the duodenum, the colon and the liver. Western blot and enzymatic activity analyses revealed an increase in the expression and activity of CYP1A1/2 and CYP3A2 isoenzymes in the esophageal, duodenal and colonic microsomes from animals treated with PB/NF. CYP1A1/2 and CYP3A2 were induced in hepatic and duodenum microsomes by treatment with CH/ABZ. Our results demonstrate differential induction of CYP along the gastrointestinal tract by known CYP hepatic inducers, being the treatment with PB/NF the best induction system of the CYPs. © 2007 Elsevier B.V. All rights reserved.
Colaborador(es) u otros Autores: Heriberto Caballero-Ortega
Víctor Dorado-Gonzalez
Norma Labra-Ruiz
Jesus Javier Espinosa-Aguirre
Josefina Gomez-Garduño
Araceli Vences-Mejıa
Fecha de publicación : 2007
Tipo de publicación: Artículo
Formato: pdf
Identificador del Recurso : 10.1016/j.etap.2007.07.004
Fuente: Environmental Toxicology and Pharmacology 24(3):297 - 303
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2913
Idioma: eng
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