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http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2945| Título : | Vaccination with a neural-derived peptide plus administration of glutathione improves the performance of paraplegic rats |
| Creador: | S. Martinón |
| Nivel de acceso: | Open access |
| Palabras clave : | Glutatión - farmacología - ratas Neuropéptidos - inmunología - ratas Paraplejía - Fisiopatología - ratas Paraplejía - psicología - ratas Paraplejía - terapia - ratas Ratas Consanguíneas Lew Ratas Sprague-Dawley Traumatismos de la Médula Espinal - Fisiopatología - ratas Traumatismos de la Médula Espinal - psicología Traumatismos de la Médula Espinal - terapia - ratas Linfocitos T - fisiología - ratas Vacunación - ratas Glutathione - pharmacology - rats Neuropeptides - immunology - rats Paraplegia - physiopathology - rats Paraplegia - psychology - rats Paraplegia- therapy - rats Rats, Inbred Lew Rats, Sprague-Dawley Spinal Cord Injuries - physiopathology - rats Spinal Cord Injuries - psychology Spinal Cord Injuries - therapy - rats T-Lymphocytes - physiology - rats Vaccination Compression; Glutathione mono-ethyl ester; Neuroprotection; Protective autoimmunity; Reimmunization; Spinal cord injury |
| Descripción : | After damage to the central nervous system (CNS) the body is protected by an adaptive immune response which is directed against myelin-associated proteins. Active immunization with nonpathogenic derivatives of CNS-associated peptides (DCAP) reduces the degeneration of neurons and promotes motor recovery after spinal cord injury (SCI) in rats. In order to improve even more the neurological outcome obtained with this therapy, either a combination of DCAP immunization plus glutathione monoethyl ester (GSHE) or a double DCAP immunization were performed. GSHE is a cell-permeant derivative of glutathione, a potent antioxidant agent that significantly inhibits lipid peroxidation after SCI. After a contusive or compressive SCI, the combination of GSHE + DCAP immunization, induced better motor recovery, a higher number of myelinated axons and better rubrospinal neuron survival than immunization alone. On the other hand, double-DCAP immunization counteracted the protective effect of DCAP therapy. Motor recovery and neuronal survival of double-immunized rats were similar to those observed in control animals (PBS-treated). Further studies revealed that double immunization was not encephalitogenic but inhibited the proliferative response of T-cells specific to the DCAP-immunized peptide. This clonal dysfunction was probably secondary to anergy. GSHE improves the protective effect induced by DCAP immunization while double immunization, reverts it. © The Authors (2007). |
| Colaborador(es) u otros Autores: | E. Garcıa N. Flores I. Gonzalez T. Ortega M. Buenrostro R. Reyes A. M. Fernandez Presas G. Guizar-Sahagún D. Correa A. Ibarra |
| Fecha de publicación : | 2007 |
| Tipo de publicación: | Artículo |
| Formato: | |
| Identificador del Recurso : | 10.1111/j.1460-9568.2007.05650.x |
| Fuente: | European Journal of Neuroscience 26(2):403 - 412 |
| URI : | http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/2945 |
| Idioma: | eng |
| Aparece en las colecciones: | Artículos |
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