Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/3118
Título : Gonadectomy and progesterone treatment induce protection in murine cysticercosis.
Creador: JOSE ANTONIO VARGAS VILLAVICENCIO
CARLOS LARRALDE RANGEL
JORGE MORALES MONTOR
Nivel de acceso: Acceso Abierto
Palabras clave : MEDICINA Y CIENCIAS DE LA SALUD
Adyuvantes inmunológicos - Metabolismo
Adyuvantes inmunológicos - Farmacologia
Cisticercosis - Parasitología
Cisticercosis - Efectos de drogas
Deshidroepiandrosterona - Metabolismo
Deshidroepiandrosterona - Farmacología
Ratones consanguíneos BALB C - Ratones
Orquiectomía
Progesterona - Administración & dosificación
Progesterona - Metabolismo
Progesterona - Uso terapéutico
Taenia - Efectos de drogas
Taenia - Crecimiento & desarrollo
Resultado del tratamiento
Adjuvants, immunologic - Metabolism
Adjuvants, immunologic - Pharmacology
Cysticercosis - Immunology
Cysticercosis - Parasitology
Cysticercus - Drug effects
Dehydroepiandrosterone- Metabolism
Dehydroepiandrosterone - Pharmacology
Mice, inbred BALB C
Orchiectomy
Ovariectomy
Progesterone - Administration & dosage
Progesterone - Metabolism
Progesterone - Therapeutic use
Progestins - Administration & dosage
Progestins - Metabolism
Progestins - Therapeutic use
Taenia - Drug effects
Taenia - Growth & development
Treatment outcome
Cisticercosis
Inmunoendocrinos
Metabolismo
Progesterona
Cysticercosis
Immunoendocrine
Progesterone
Taenia
Descripción : The effects of progesterone on castrated mice of both sexes infected with Taenia crassiceps cysticerci were studied. Gonadectomy and treatment with progesterone before infection decreased parasite loads by 100% compared with intact uninfected mice. mRNA levels of IFN gamma and IL-2 (typically associated to Th1-like profiles) were markedly decreased in infected gonadectomized (Gx) mice, whereas progesterone treatment of infected Gx mice did not affected its expression. mRNA levels of IL-4, and IL-10 (typically associated with Th2-like profiles) were reduced by gonadectomy, whereas restitution with progesterone did not affected this pattern in infected Gx progesterone-treated mice. Infection markedly induced expression of progesterone receptor isoform A in splenocytes of Gx mice (5-fold), whereas isoform B had no changes. Progesterone metabolism to dehydroepiandrosterone (DHEA) in Gx animals was increased 3-fold only in infected progesterone-treated uninfecteds of both sexes, but was not detectable in infected Gx progesterone-treated mice. Conversely, DHEA levels increased 100-fold in infected Gx progesterone-treated mice. However, androgen receptor expression in splenocytes of male mice showed a reduction by gonadectomy, and by infection, whereas in females AR expression showed no changes in the different mouse groups. These results suggest that progesterone, through its metabolism to DHEA, negatively affects the establishment, growth, and reproduction of Taenia crassiceps, by a mechanism that does not implicate a classic genomic pathway involving a nuclear androgen receptor.
Editorial : Wiley
Fecha de publicación : 2006
Tipo de publicación: Artículo
Formato: Adobe PDF
Identificador del Recurso : 10.1111/j.1365-3024.2006.00906.x
Fuente: Parasite Immunology 28(12):667-674
URI : http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/3118
Aparece en las colecciones: Artículos Investigadores

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