1. Instituto Nacional de Pediatría
2. INP
3. Artículos Investigadores

Título :	Serotonin and 5-hydroxy-indole-acetic acid contents in dorsal raphe and suprachiasmatic nuclei in normal, malnourished and rehabilitated rats under 24 h of sleep deprivation.
Creador:	ALFONSO BENITO ALFARO RODRIGUEZ RIGOBERTO GONZALEZ PIÑA ANGELICA GONZALEZ MACIEL EMILIO ARCH TIRADO
Nivel de acceso:	Acceso Abierto
Palabras clave :	MEDICINA Y CIENCIAS DE LA SALUD Conducta animal - Ratas Cromatografía líquida de alta presión - Métodos - Ratas Ácido hidroxiindolacético - Metabolismo - Ratas Desnutrición - Metabolismo - Ratas Desnutrición - Patología - Ratas Desnutrición - Rehabilitación - Ratas Núcleos del rafe - Metabolismo - Ratas Sprague - Dawley - Ratas Serotonina - Metabolismo - Ratas Privación de sueño - Metabolismo - Ratas Núcleo supraquiasmático - Metabolismo - Ratas Behavior, animal - Rats Chromatography, high pressure liquid - Methods - Rats Hydroxyindoleacetic acid - Metabolism - Rats Malnutrition - Metabolism - Rats Malnutrition - Pathology - Rats Malnutrition - Rehabilitation - Rats Raphe nuclei metabolism - Rats Serotonin - Metabolism - Rats Sleep deprivation - Metabolism - Rats Suprachiasmatic nucleus - Metabolism - Rats Serotonina Acido 5-Hidroxi-Indol-Acético Dorsal núcleos del rafe Núcleo supraquiasmático Privación del sueño, ratas Serotonin 5-Hydroxy-Indole-Acetic Acid
Descripción :	It has been discussed that serotonin (5-HT) could be involved in the effects of sleep deprivation (SD) and/or malnutrition (M) on the sleep-wake cycle. The aim of this work was to study the effects of the M, SD and its interaction on 5-HT and 5-hydroxy-indole-acetic acid (5-HIAA) contents in the dorsal raphe (DR) and the suprachiasmatic nuclei (SCN), two sleep-wake cycle regulators. Forty-eight puppets rats were obtained from mothers fed with low or normal casein diet. They were allocated in 3 groups (n = 16 each): prenatal/postnatal casein malnutrition (6/6%), prenatal casein malnutrition/nutritional casein rehabilitation (6/25%) and prenatal/postnatal casein well-nourished state (25/25%). When rats were 60 days old, 24 animals were exposed to sleep deprivation by means of forced locomotion during 24 h. The remaining 24 were kept under normal conditions of sleep-wake cycle. Then, all animals were sacrificed by decapitation. DR and SCN were dissected and processed to determine the 5-HT and 5-HIAA contents by means of HPLC. It was observed that 6/6% rats showed a 5-HT increase (DR p < 0.011; SCN p < 0.019) as well as in SD (DR p < 0.0008; SCN p < 0.0009) with respect to 25/25% rats. No differences were found in 6/25% rats. Therefore, 5-HIAA decreased significantly in both nuclei in all the groups, notably in M + SD animals (DR p < 0.001; SCN p < 0.001). We conclude that the sleep-wake cycle disruptions produced by chronic M and SD are mediated in part by a synergistic effect on 5-HT in the DR-SCN pathway, perhaps due to a delay in the development of such brain structures. © 2006 Elsevier B.V. All rights reserved.
Editorial :	Elsevier
Fecha de publicación :	2006
Tipo de publicación:	Artículo
Formato:	Adobe PDF
Identificador del Recurso :	10.1016/j.brainres.2006.06.069
Fuente:	Brain Research 1110(1):95 - 101
URI :	http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/3122
Aparece en las colecciones:	Artículos Investigadores

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